MRAS

Gene Symbol:
MRAS
HGNC:7227
Locus Group:
protein-coding gene
Locus Type:
gene with protein product
Location:
3q22.3
Filters:

Definitive classifications

Noonan syndrome 11
Submitted as: OMIM:618499
AD
01/27/2025
Evaluated
07/02/2025
Submitted

Strong classifications

Noonan syndrome 11
Submitted as: OMIM:618499
AD
10/07/2020
Evaluated
10/08/2020
Submitted
Noonan syndrome 11
Submitted as: OMIM:618499
AD
10/09/2020
Evaluated
11/09/2020
Submitted
Noonan syndrome 11
Submitted as: OMIM:618499
AD
02/08/2023
Evaluated
11/30/2023
Submitted

Moderate classifications

Noonan syndrome 11
Submitted as: OMIM:618499
AD
05/31/2019
Evaluated
12/24/2020
Submitted
AD
12/14/2022
Evaluated
12/05/2025
Submitted
ClinGen
Evidence:

MRAS was reported in relation to autosomal dominant Noonan syndrome as early as 2017 (Higgins et... Read more

Supportive classifications

Noonan syndrome
Submitted as: Orphanet:648
AD
09/14/2021
Evaluated
09/14/2021
Submitted

No Known Disease Relationship classifications

Noonan syndrome-like disorder with loose anagen hair
AD
04/30/2018
Evaluated
12/05/2025
Submitted
ClinGen
Evidence:

No published evidence to date has implicated an association between MRAS variants and NS/LAH.

... Read more
Noonan syndrome with multiple lentigines
AD
04/30/2018
Evaluated
12/05/2025
Submitted
ClinGen
Evidence:

No published evidence to date has implicated an association between MRAS variants and NSML.

cardiofaciocutaneous syndrome
AD
04/30/2018
Evaluated
12/05/2025
Submitted
ClinGen
Evidence:

No published evidence to date has implicated an association between MRAS variants and CFC.

AD
04/30/2018
Evaluated
12/05/2025
Submitted
ClinGen
Evidence:

No published evidence to date has implicated an association between MRAS variants and CS.

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