TP63

Gene Symbol:
TP63
HGNC:15979
Locus Group:
protein-coding gene
Locus Type:
gene with protein product
Location:
3q28
Filters:

ADULT syndrome classifications

ADULT syndrome
Submitted as: OMIM:103285
AD
02/07/2025
Evaluated
07/02/2025
Submitted
ADULT syndrome
Submitted as: Orphanet:978
AD
09/14/2021
Evaluated
09/14/2021
Submitted

Ankyloblepharon-ectodermal defects-cleft lip/palate syndrome classifications

ankyloblepharon-ectodermal defects-cleft lip/palate syndrome
Submitted as: OMIM:106260
AD
05/24/2023
Evaluated
07/02/2025
Submitted
ankyloblepharon-ectodermal defects-cleft lip/palate syndrome
Submitted as: Orphanet:1071
AD
09/14/2021
Evaluated
09/14/2021
Submitted

EEC syndrome classifications

AD
09/14/2021
Evaluated
09/14/2021
Submitted

Ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3 classifications

ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3
Submitted as: OMIM:604292
AD
08/31/2018
Evaluated
12/24/2020
Submitted
ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3
Submitted as: OMIM:604292
AD
07/03/2023
Evaluated
11/30/2023
Submitted
ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3
AD
10/17/2024
Evaluated
12/05/2025
Submitted
ClinGen
Evidence:

TP63 was first reported in relation to AD TP63-related ectodermal dysplasia spectrum with limb an... Read more

Limb-mammary syndrome classifications

limb-mammary syndrome
Submitted as: OMIM:603543
AD
05/24/2023
Evaluated
07/02/2025
Submitted
limb-mammary syndrome
Submitted as: Orphanet:69085
AD
09/14/2021
Evaluated
09/14/2021
Submitted

Premature ovarian failure 21 classifications

premature ovarian failure 21
Submitted as: OMIM:620311
AD
07/03/2023
Evaluated
11/30/2023
Submitted
premature ovarian failure 21
AD
02/14/2025
Evaluated
07/02/2025
Submitted

Rapp-Hodgkin syndrome classifications

Rapp-Hodgkin syndrome
Submitted as: OMIM:129400
AD
09/01/2017
Evaluated
07/02/2025
Submitted
Rapp-Hodgkin syndrome
AD
09/16/2019
Evaluated
07/02/2025
Submitted

Split hand-foot malformation classifications

split hand-foot malformation
Submitted as: Orphanet:2440
AD
09/14/2021
Evaluated
09/14/2021
Submitted

Split hand-foot malformation 4 classifications

split hand-foot malformation 4
AD
07/20/2021
Evaluated
10/27/2022
Submitted

TP63-related ectodermal dysplasia spectrum with limb and orofacial malformations classifications

TP63-related ectodermal dysplasia spectrum with limb and orofacial malformations
AD
01/17/2025
Evaluated
12/15/2025
Submitted

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