Gene Symbol:
BRAF
HGNC:1097
Locus Group:
protein-coding gene
Locus Type:
gene with protein product
Location:
7q34
Filters:

Definitive classifications

Noonan syndrome 7
Submitted as: OMIM:613706
AD
10/09/2020
Evaluated
11/09/2020
Submitted
cardiofaciocutaneous syndrome 1
Submitted as: OMIM:115150
AD
10/09/2020
Evaluated
11/09/2020
Submitted
cardiofaciocutaneous syndrome 1
Submitted as: OMIM:115150
AD
07/22/2015
Evaluated
09/11/2023
Submitted
cardiofaciocutaneous syndrome
AD
07/24/2018
Evaluated
04/21/2024
Submitted
cardiofaciocutaneous syndrome 1
Submitted as: OMIM:115150
AD
01/10/2018
Evaluated
03/02/2021
Submitted
LEOPARD syndrome 3
Submitted as: OMIM:613707
AD
09/01/2017
Evaluated
09/11/2023
Submitted
Noonan syndrome 7
Submitted as: OMIM:613706
AD
09/01/2017
Evaluated
09/11/2023
Submitted

Strong classifications

LEOPARD syndrome 3
Submitted as: OMIM:613707
AD
10/07/2020
Evaluated
10/08/2020
Submitted
LEOPARD syndrome 3
Submitted as: OMIM:613707
AD
11/19/2020
Evaluated
11/30/2023
Submitted
Noonan syndrome 7
Submitted as: OMIM:613706
AD
10/07/2020
Evaluated
10/08/2020
Submitted
cardiofaciocutaneous syndrome 1
Submitted as: OMIM:115150
AD
10/07/2020
Evaluated
10/08/2020
Submitted
Noonan syndrome 7
Submitted as: OMIM:613706
AD
03/06/2023
Evaluated
11/30/2023
Submitted
cardiofaciocutaneous syndrome 1
Submitted as: OMIM:115150
AD
07/05/2023
Evaluated
11/30/2023
Submitted

Moderate classifications

Noonan syndrome 7
Submitted as: OMIM:613706
AD
01/10/2018
Evaluated
03/02/2021
Submitted
AD
07/24/2018
Evaluated
04/21/2024
Submitted

Supportive classifications

cardiofaciocutaneous syndrome
Submitted as: Orphanet:1340
AD
09/14/2021
Evaluated
09/14/2021
Submitted
Noonan syndrome with multiple lentigines
Submitted as: Orphanet:500
AD
09/14/2021
Evaluated
09/14/2021
Submitted

Limited classifications

anaplastic astrocytoma
AD
01/10/2018
Evaluated
09/28/2021
Submitted
Noonan syndrome with multiple lentigines
AD
07/24/2018
Evaluated
04/21/2024
Submitted
LEOPARD syndrome 3
Submitted as: OMIM:613707
AD
08/31/2018
Evaluated
03/02/2021
Submitted

Disputed Evidence classifications

The GenCC data are available free of restriction under a CC0 1.0 Universal (CC0 1.0) Public Domain Dedication. The GenCC requests that you give attribution to GenCC and the contributing sources whenever possible and appropriate. The accepted Flagship manuscript is now available from Genetics in Medicine (https://www.gimjournal.org/article/S1098-3600(22)00746-8/fulltext).

The information on this website is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Individuals should not change their health behavior solely on the basis of information contained on this website. The GenCC does not independently verify the submitted information. Though the information is obtained from sources believed to be reliable, no warranty, expressed or implied, is made regarding accuracy, adequacy, completeness, reliability or usefulness of any information. This disclaimer applies to both isolated and aggregate uses of the information. The information is provided on an "as is" basis, collected through periodic submission and therefore may not represent the most up-to-date information from the submitters. If you have questions about the medical relevance of information contained on this website, please see a healthcare professional; if you have questions about specific gene-disease claims, please contact the relevant sources; and if you have questions about the representation of the data on this website, please contact gencc@thegencc.org.