The ORC4 gene is located on chromosome 2 at 2q23.1 and encodes the origin recognition complex, subunit 4, which binds origins of replication and is required to assemble the pre-replication complex necessary to initiate DNA replication. ORC4 was first reported in relation to autosomal recessive Meier-Gorlin syndrome 4 in 2011 (MIM 613800) (Guernsey et al., PMID: 21358631). Meier-Gorlin syndrome 4 is a syndromic disorder characterized by short stature,
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