COL1A2 was first reported in relation to congenital heart disease in 2017 (Jin et al., PMID: 28991257). This gene-disease relationship in the literature reports both autosomal dominant and recessive cases, so the mode of inheritance is currently undetermined. Four unique variants (1 homozygous missense, 3 heterozygous missense) that have been reported in four probands with CHD in three publications are included in this curation (PMID: 28991257, 33064175, 35885997). However, these variants were not scored due to a high minor allele frequency in gnomAD v.4 or a low REVEL score. This gene-disease relationship is supported by expression data in mouse cardiac tissues (PMID: 18816857). In summary, the evidence supporting the relationship between COL1A2 and congenital heart disease has been disputed, and no valid evidence remains to support the claim. More evidence is needed to either support or entirely refute the role COL1A2 plays in this disease. This classification was approved by the ClinGen Congenital Heart Disease GCEP on the meeting date September 9th, 2024 (SOP Version 11).
The GenCC data are available free of restriction under a CC0 1.0 Universal (CC0 1.0) Public Domain Dedication. The GenCC requests that you give attribution to GenCC and the contributing sources whenever possible and appropriate. The accepted Flagship manuscript is now available from Genetics in Medicine (https://www.gimjournal.org/article/S1098-3600(22)00746-8/fulltext).
The information on this website is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Individuals should not change their health behavior solely on the basis of information contained on this website. The GenCC does not independently verify the submitted information. Though the information is obtained from sources believed to be reliable, no warranty, expressed or implied, is made regarding accuracy, adequacy, completeness, reliability or usefulness of any information. This disclaimer applies to both isolated and aggregate uses of the information. The information is provided on an "as is" basis, collected through periodic submission and therefore may not represent the most up-to-date information from the submitters. If you have questions about the medical relevance of information contained on this website, please see a healthcare professional; if you have questions about specific gene-disease claims, please contact the relevant sources; and if you have questions about the representation of the data on this website, please contact gencc@thegencc.org.