There is only one case reported of a TNNI3 variant in an ARVC patient (30385303) in a Chinese patient. This proband presented in VT of LBBB superior axis morphology and has TWI in leads V1-V4, meeting ARVC TFC criteria. This variant, however is present in higher than expected prevalence in the East Asian population. Otherwise, in other studies (29709087) of 137 patients sequenced for TNNI3, no pathogenic variants were found. Therefore, there is currently no evidence to suggest a role of TNNI3 in pathogenesis of ARVC.
The GenCC data are available free of restriction under a CC0 1.0 Universal (CC0 1.0) Public Domain Dedication. The GenCC requests that you give attribution to GenCC and the contributing sources whenever possible and appropriate. The accepted Flagship manuscript is now available from Genetics in Medicine (https://www.gimjournal.org/article/S1098-3600(22)00746-8/fulltext).
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