TNNC2 was initially curated at expert request. No convincing evidence for a causal role for TNNC2 in HCM has been reported. Although TNNC2 encodes part of the troponin complex, which has been implicated in HCM, there is no direct evidence for an association between TNNC2 and HCM. There is no convincing case control evidence for an association between TNNC2 and HCM. The mechanism of pathogenicity is unknown. In summary, there is no reported evidence to support this gene-disease association with HCM. This gene-disease pair was originally evaluated by the HCM GCEP on 04/04/2017. It was reevaluated on 04/12/2023 by the HCVD GCEP. As a result of this reevaluation, the classification did not change.
The GenCC data are available free of restriction under a CC0 1.0 Universal (CC0 1.0) Public Domain Dedication. The GenCC requests that you give attribution to GenCC and the contributing sources whenever possible and appropriate. The accepted Flagship manuscript is now available from Genetics in Medicine (https://www.gimjournal.org/article/S1098-3600(22)00746-8/fulltext).
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