No evidence for a causal role for RXRA in congenital heart disease has been reported. Although deletion of this gene in mouse models has been variably associated with congenital heart anomalies, no reports have directly implicated the gene for structural CHDs in humans. This classification was approved by the ClinGen Congenital Heart Disease GCEP on the meeting date October 1st, 2024 (SOP Version 11).
The GenCC data are available free of restriction under a CC0 1.0 Universal (CC0 1.0) Public Domain Dedication. The GenCC requests that you give attribution to GenCC and the contributing sources whenever possible and appropriate. The accepted Flagship manuscript is now available from Genetics in Medicine (https://www.gimjournal.org/article/S1098-3600(22)00746-8/fulltext).
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